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References 1. Cup AG, Lacey JV Jr, Carreon D, Hoover RN. Rossouw JE, Anderson GL, Prentice RL, et al. Dangers and great things about estrogen plus progestin in healthful postmenopausal women: principal outcomes from the Women’s Wellness Initiative randomized managed trial. JAMA 2002;288:321?33.. Breast HRT and cancer The medical community has been debating for several years whether, also to what extent, postmenopausal hormone therapy use is connected with a higher threat of breast cancer, says Professor Amos Pines, President of the International Menopause Society.